![]() Eight rabbits were injected with normal saline as a control. Upper airway obstruction was induced by injecting botulinum toxin type A (2.5 U in 8 rabbits, 5.0 U in 10 rabbits, and 7.5 U in 1 rabbit) into the genioglossus. Intervention Sleep was induced by intramuscular injection of 0.3 mL/kg of tiletamine hydrochloride plus zolazepam hydrochloride and 0.2 mL/kg of xylazine. Subjects A total of 27 New Zealand white male rabbits were used. ![]() Objective To establish a new OSA animal model simulating real upper airway conditions during sleep.ĭesign and Setting In vivo animal study at an academic tertiary referral center. Importance This study presents an innovative method for developing a neuromuscular model of obstructive sleep apnea (OSA). Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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